The consolidated Institute’s research activities will continue to focus on Inherited, Tropical & Rare Diseases; the development of gene therapies and genome editing strategies; Pharmacological Innovation (Pgx); Cancer; Breath Biopsy and Biomarkers; advanced medical screening technologies and methods, as well as Clinical Trial Sponsorship. Educating and enabling practical experience for student Medical Doctors, Clinicians, and Technologists is fundamental to our activities. We promote education and scientific dissemination actions across different types of audiences, reaching broad sectors of local and international society in conjunction with our experts, strategic partners and institutions. Our facilities provide a unique experience for students and professors from different academic universities and institutes the ability to work collaboratively on a unified project and then extend this research into the community with our mobile clinics and rural track programs. We facilitate the mandatory 120 hours of face-to-face dialogues with individuals in rural and metropolitan areas to improve Public Health and provide the students with practical experience via our collaboration with the SUS Mias Medicos (rural and metropolitan) and Macieo's Brota na Grata initiatives. The data collected is used to influence policymaking and improve SUS healthcare systems that experience higher incidences of diseases, ​barriers to transportation and access to care in a predominance of low-income households.​ We also sponsor medical procedures, provision of advanced personalized medical technologies, and innovation transfers via seminars developed by our 80+ international consortium members and from their National projects we will transfer to Brazil. We provide BOLSA's , international student exchanges, and support for Masters, PhD, and Post-Doctoral candidates.

​Incorporating H2CI’s extensive European Union and global collaboration partners and projects across 80 countries, we will continue to advance the state of the art for Cross-Border Clinical Trials, AI-assisted diagnosis, innovative gene therapy (ATP) as well as, Personal Care Records, integrated Clinical PGx, Hospital or UTI@Home Personalized Medicine; Medical Software Applications; Professional Education & Conferences; Integrated Community Care and Social Programs.

Some of our more advanced medical projects and applications for genomics and precision public health incorporate the power of Artificial Intelligence to assist medical professionals with a risk-based approach to diagnosis. This complements their professional skills and experiences. They help reduce costs without sacrificing assurance of data reliability, investigator compliance, or meeting regulatory reporting obligations.

​Our Regulatory Affairs activities include coordinating with Research Ethics Committees, medical device approval authorities at country levels with Brazilian- ANVISA, the European Medicines Agency (EMA), and US Food and Drug Administration (FDA). We can help you design a clinical study tailored to your product’s specific needs and collect data efficiently while qualifying actions under the Medical Device Single Audit Program (MDSAP) regulatory requirements.

Clinical project management is important to ensure that your trial runs as smoothly as possible. Our clinical project management team has decades of experience managing trials. We emphasize efficiency in conducting clinical trials while maintaining exemplary quality and compliance. Our team can complete clinical site assessments, help you prepare documentation for Ethics Committees, complete the site initiation and training, and complete the necessary steps for trial closeout. Our experience across a multitude of trial sites around the world has taught us how to evaluate potential sites, and the right questions to ask to determine the best fit for each clinical trial. Smart site selection contributes greatly to completing a clinical trial on time and on budget.

Our protocol development process involves working in collaboration with clinical experts and other study stakeholders to identify reasonable performance goals, determine appropriate examinations and procedures, and define the right patient population. This ensures the clinical study protocol will successfully implement the study plan and maintain compliance with all applicable regulatory requirements. A well-written protocol is essential to maximizing efficiency and minimizing risks in gathering the necessary clinical data for your product. We can create case report forms (CRFs) that comply with the Brazilian Registry of Clinical Trials (ReBEC), the Pan American Health Organization (OPAS), and the World Health Organization Good Clinical Practice (GCP) ICH E6(R3) standards. Our CRFs are customized to suit the project type and individual requirements using AI Assisted Automated Clinical Trial Eligibility, Surveillance, Dash-boarding and Reporting. Active clinical monitoring can help predict potential clinical trial challenges or at least identify issues early so they may be addressed before they lead to significant delays leading to increased costs, or derail the trial completely.